Process Development

<h3><span style="color:#8f28fe;"><a href="https://www.youtube.com/watch?v=Ep6swJO--qI" target="_blank" rel="noreferrer noopener"><span style="color:#8f28fe;"><strong>How does SkillPak work, </strong><strong>click here for the video!</strong></span></a></span></h3> <p>SkillPak pre-packed columns are designed for your purification and separation tasks from platform design to pilot scale. They are ready to use and show excellent physical strength and ideal flow characteristics for downstream processing. Pre-packed with TOYOPEARL, TSKgel, or Ca++Pure-HA process chromatography media, these columns offer superior evaluation of biomolecules, such as monoclonal antibodies, proteins, and oligonucleotides.</p> <p>All SkillPak columns guarantee optimal performance and can be operated with standard low- or medium-pressure liquid chromatography systems. They are reproducibly packed and take into account the varying compressibility of each resin. This provides an accurate representation of conditions found in full-scale columns.</p> <p>SkillPak 1 (7 mm ID × 2.5 cm) and 5 (8 mm ID × 10 cm) columns are designed for fast method development, resin screening, or sample concentration.<br /><br /></p> <p><em><strong><a href="https://www.separations.eu.tosohbioscience.com/solutions/process-media-products/process-development/skillpak/skillpak-1-columns" target="_blank" rel="noreferrer noopener">More information SkillPak 1 mL (7 mm ID × 2.5 cm)</a>        </strong></em><em><strong><a href="https://www.separations.eu.tosohbioscience.com/solutions/process-media-products/process-development/skillpak/skillpak-5-columns" target="_blank" rel="noreferrer noopener">More information SkillPak 5 mL (8 mm ID x 10 cm)</a></strong></em><em><strong><a href="https://www.separations.eu.tosohbioscience.com/solutions/process-media-products/process-development/skillpak/skillpak-1-ml" target="_blank" rel="noreferrer noopener"><br /></a></strong></em></p>

<h3><span style="color:#8f28fe;"><a href="https://www.youtube.com/watch?v=Ep6swJO--qI" target="_blank" rel="noreferrer noopener"><span style="color:#8f28fe;"><strong>How does SkillPak work, </strong><strong>click here for the video!</strong></span></a></span></h3> <p>SkillPak pre-packed columns are designed for your purification and separation tasks from platform design to pilot scale. They are ready to use and show excellent physical strength and ideal flow characteristics for downstream processing. Pre-packed with TOYOPEARL, TSKgel, or Ca++Pure-HA process chromatography media, these columns offer superior evaluation of biomolecules, such as monoclonal antibodies, proteins, and oligonucleotides.</p> <p>All SkillPak columns guarantee optimal performance and can be operated with standard low- or medium-pressure liquid chromatography systems. They are reproducibly packed and take into account the varying compressibility of each resin. This provides an accurate representation of conditions found in full-scale columns.</p> <p>SkillPak 50 (2.5 cm ID x 10 cm L) and 200 (5.0 cm ID x 10 cm L) allow seamless scale-up of chromatography processes after method development on the 1 mL and 5 mL columns.<br /><br /></p> <p><em><strong><a href="https://www.separations.eu.tosohbioscience.com/solutions/process-media-products/process-development/skillpak/skillpak-50-columns" target="_blank" rel="noreferrer noopener">More information SkillPak 50 mL (2.5 cm ID × 10 cm)</a>        </strong></em><em><strong><a href="https://www.separations.eu.tosohbioscience.com/solutions/process-media-products/process-development/skillpak/skillpak-200-columns" target="_blank" rel="noreferrer noopener">More information SkillPak 200 mL (5.0 cm ID x 10 cm)</a></strong></em></p>

<p>ToyoScreen RoboColumns are miniaturized chromatographic columns pre-packed with TOYOPEARL ion exchange, mixed-mode, hydrophobic interaction or affinity media. Available in different volumes, they are designed to operate with a robotic liquid handling system, such as the Freedom EVO® from TECAN. This approach allows automated high-throughput, small-scale bio-chromatographic separations of protein samples by running up to eight individual columns simultaneously. ToyoScreen RoboColumns are packed with TOYOPEARL to our specifications by Repligen and are supplied in strips of 8 columns.</p> <p>ToyoScreen RoboColumns can be used in a wide range of applications, including individual and parallel resin screening, optimization of separation conditions, scale-down experiments, as well as high throughput sample preparation. Binding and elution conditions, washing parameters, etc. can be investigated to explore the design space of the particular molecule’s purification process.<br /><br /><em><strong><a href="https://www.separations.eu.tosohbioscience.com/solutions/process-media-products/process-development/robocolumns" target="_blank" rel="noreferrer noopener">More information</a></strong></em></p>

<p>TOYOPEARL Resin Seeker 96-well plate kits are packed with TOYOPEARL and TOYOPEARL GigaCap resins and are available in the configurations detailed below. All components necessary to run an experiment are included in each kit: a wash plate and collection plate are included in each 96-well plate package.</p> <p>These 96-well plate kits are manufactured by Orochem and sold exclusively by Tosoh Bioscience.<br /><br /></p> <p><strong><em><a href="https://sebio.os-rieder.ch/img/cms/Resin%20seeker%2096-well%20plate%20kits.pdf" target="_blank" rel="noreferrer noopener">More information</a></em></strong></p>

<p>LabPak products are multi-milliliter containers of TOYOPEARL and TSKgel bulk media products. Typically they contain three or four different ligand types offered for a particular chromatography mode.<br />They are useful for developmental engineers who wish to familiarize themselves with resin physical properties in different buffer systems.<br />The larger resin amounts in LabPak products allow the packing of wider I.D. and longer columns than available in the ToyoScreen products. This helps the developmental chemist or engineer to better measure under actual packing conditions.</p> <p><em><strong><a href="https://www.separations.eu.tosohbioscience.com/solutions/process-media-products/process-development/labpak-media" target="_blank" rel="noreferrer noopener">More information</a><br /></strong></em></p>

<p>SkillPak BIO pre-packed columns are part of Tosoh Bioscience’s holistic solution for the development of multicolumn chromatography (MCC) processes. SkillPak BIO pre-packed columns are the perfect complement to the OctaveTM BIO MCC system and TOYOPEARL resins, offering a unique and comprehensive solution for developing MCC processes. Designed with dedicated dimensions and comprehensive TOYOPEARL resins for MCC applications, SkillPak BIO is designed to unlock the best MCC performances. </p>